Month: February 2020

C60 and Muscle fatigue

Study: C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

The use of C60FAS, even at a low therapeutic dose (0.1–0.15 mg/kg) leads to a reduction in the recovery time of the muscle contraction force (after its complete exhaustion state) on the one hand, and an increase in the time of the muscle active work (endurance) until fatigue development on the other. This result illustrates the effect of C60FAS, along with other possible mechanisms, on prooxidant-antioxidant homeostasis in the muscle tissue of rats.

For the full article: Here

C60 Antioxidant Action- Possible Mechanisms of Fullerene

Biomed Research InternationalPublished online 2013 Oct 8. 
V. A. Chistyakov, Yu. O. Smirnova, E. V. Prazdnova, and A. V. Soldatov 

 “Abstract: Novel mechanism of antioxidant activity of buckminsterfullerene C60 based on protons absorbing and mild uncoupling of mitochondrial respiration and phosphorylation was postulated. In the present study we confirm this hypothesis using computer modeling based on Density Functional Theory. Fullerene’s geroprotective activity is sufficiently higher than those of the most powerful reactive oxygen species scavengers. We propose here that C60 has an ability to acquire positive charge by absorbing inside several protons and this complex could penetrate into mitochondria. Such a process allows for mild uncoupling of respiration and phosphorylation. This, in turn, leads to the decrease in ROS production.”

Full study available here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816026/